Method for Treating Cervical Lesions May Pose Pregnancy Risks

By Karen Pallarito
HealthDay Reporter
Saturday, June 7, 2008; 3:00 AM

Copyright © 2008 ScoutNews, LLC. All rights reserved.

FRIDAY, June 6 (HealthDay News) -- A popular type of surgery for removing abnormal cells from the cervix -- a problem that could lead to cervical cancer if left untreated -- may put women at risk of pregnancy complications.

Women who had this procedure, known as loop electrosurgical excision procedure, or LEEP, were at greater risk of delivering preterm babies or having a low-birth-weight infant, according to British researchers.

Doctors should use caution in treating young women with mild cervical abnormalities or precancerous cells, the study authors concluded in a paper published recently in the medical journal The Lancet.

"Women should seek detailed information on efficacy but also on long-term pregnancy-related morbidity before they consent," lead study author Dr. Maria Kyrgiou of Central Lancashire Teaching Hospitals in Preston, Great Britain, told HealthDay.

LEEP is one of several surgical techniques for removing abnormal or precancerous cells from the cervix.

After numbing the cervix with local anesthesia, an electrically charged wire loop is inserted through the vagina, explains the American College of Obstetricians and Gynecologists. The loop, acting as a scalpel, cuts away a thin layer of tissue, removing the abnormal cells.

Other methods, including cold knife conization, laser ablation and laser conization, also remove or destroy suspect tissue while preserving cervical function, the British researchers noted. But the effect of these various treatments on future fertility and pregnancies has been unclear.

To assess the potential impact, Kyrgiou and her colleagues analyzed data from 27 previous studies.

Cold knife conization, which involves the excision of a cone-shaped piece of tissue, increased the likelihood of preterm birth and delivering a low-birth-weight infant by two-and-a-half times, and tripled the risk for Caesarean section, compared with women who did not have this procedure.

LEEP increased the risk of preterm delivery and delivering a low-birth-weight infant by 70 percent and 82 percent, respectively. It nearly tripled the likelihood of premature rupturing of the cervical membranes, the study authors found.